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首頁 > 期刊 > 結(jié)構(gòu)化學(xué) > Synthesis, Crystal Structure and Antitumor Activity of N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N'-((E)-styryl)ureas 【正文】

Synthesis, Crystal Structure and Antitumor Activity of N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N'-((E)-styryl)ureas

1 3 urea crystal structure 
作者：宋新建; 王旭梅; 孫琦; 黃生田; 王艷 College; of; Chemistry; and; Environmental; Engineering; Sichuan; University; of; Science; and; Engineering; Zigong; 643000; China; School; of; Chemical; and; Environmental; Engineering; Hubei; University; for; Nationalities; Enshi; 445000; China

摘要：N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N?-((E)-styryl)ureas 4 a~4 i were designed and synthesized as antitumor agents, and their structures were characterized by IR, 1 H NMR, 13 C NMR,MS and elemental analysis. The single crystal of compound 4 a, C17 H13 FN4 OS, was also determined by X-ray crystallography. Crystal data: monoclinic, space group P21/n, a = 4.9401(8), b= 8.7100(15), c = 36.604(6) A,β= 93.320(3)°, V = 1572.4(5) A3, Z = 4, F(000)= 704, Dc = 1.438 g/cm3,μ= 0.228 mm-1, R = 0.0600 and wR = 0.1448 for 2743 independent reflections(Rint =0.0418) and 2174 observed ones(I > 2σ(I)). The in vitro antitumor activities of compounds 4 a~4 i were preliminarily evaluated by the standard MTT assay.

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結(jié)構(gòu)化學(xué)雜志， 月刊，本刊重視學(xué)術(shù)導(dǎo)向，堅持科學(xué)性、學(xué)術(shù)性、先進性、創(chuàng)新性，刊載內(nèi)容涉及的欄目：有機化學(xué)、無機化學(xué)、合成化學(xué)、結(jié)構(gòu)化學(xué)、材料科學(xué)、藥物化學(xué)、晶體學(xué)、理論化學(xué)等。等。于1982年經(jīng)新聞總署批準的正規(guī)刊物。

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